Ornithine Alpha-Ketoglutarate
What does it do?
The amino acids ornithine and glutamine are combined to form ornithine alpha-ketoglutarate
(OKG).
OKG has been shown to improve protein retention,
wound repair, and immune function in
hospitalized patients partly by increasing levels of growth-promoting (anabolic) hormones such
as insulin and growth hormone.1 In a large, well-controlled trial,2
nonhospitalized elderly people benefited from 10 grams per day of OKG as they recovered from
various illnesses or surgery, showing improved appetite, weight gain, muscle growth, reduced
need for medical care, and improved quality of life. No studies on muscle growth in athletes
using OKG have been published.
Where is it found?
Although the amino acids that comprise OKG are
present in protein foods such as meat and
poultry and fish, the OKG compound is found only in
supplements.
OKG has been used in
connection with the following condition (refer to the individual
health concern for complete information):
Who is likely to be deficient?
A deficiency of OKG has not been reported.
How much is usually taken?
Optimal levels remain unknown, though 10 grams per day has been used in clinical
trials.
Are there any side effects or interactions?
No side effects have been reported with the use of OKG.
No clear interactions between OKG and other nutrients have been established.
At the time of writing, there were no well-known drug interactions
with Ornithine Alpha-Ketoglutarate.
References
1. Le Boucher J, Cynober LA. Ornithine alpha-ketoglutarate: the puzzle.
Nutrition 1998;14:870–3 [review].
2. Brocker P, Vellas B, Albarede J, et al. A two-centre, randomized,
double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent
subjects. Age Aging 1994;23:303–6.
Copyright © 2004 Healthnotes, Inc. All rights reserved.
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purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. Information expires March 2005.
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Reliable and relatively consistent scientific data showing a substantial health benefit.
For an herb, supported by traditional use but
minimal or no scientific evidence. For a supplement, little scientific support and/or minimal
health benefit.
