What does it do?
Histidine is called a semi-essential amino acid
(protein building block) because adults generally produce adequate amounts but children may
not. Histidine is also a precursor of histamine, a compound released by immune system cells
during an allergic reaction.
Who is likely to be deficient?
According to limited research, many people with rheumatoid arthritis have low levels of histidine.
Taking histidine supplements might improve arthritis symptoms in some people.1
How much is usually taken?
Most people do not need to supplement histidine. Optimal levels for others remain unknown.
Human research has used between 1 gram and 8 grams per day.
Are there any side effects or interactions?
No side effects have been reported with histidine. However, people with kidney or liver
disease should not consume large amounts of amino acids
without consulting a healthcare professional.
At the time of writing, there were no well-known drug interactions
with histidine.
References
1. Gerber DA, Gerber MG. Specificity of a low free histidine
concentration for rheumatoid arthritis. J Chronic Dis 1977;30:115–27.
Copyright © 2004 Healthnotes, Inc. All rights reserved.
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The information presented in Healthnotes is for informational
purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. Information expires March 2005.
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