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Non-Nutritive and Artificial Sweeteners
Also indexed as: Acesulfame K, Alitame, Artificial Sweeteners,
Ascesulfame Potassium, Aspartame, Cyclamate, Equal®, NutraSweet®, Saccharin,
Sucralose, Sunette®, Sweet ’N Low®
Today, saccharin, aspartame, sucralose, and acesulfame K are the most
widely used artificial sweeteners.
Non-nutritive sweeteners, also called artificial or non-caloric sweeteners, are intensely
sweet synthetic substances, often used in place of other sugars in food manufacturing and
cooking because they are calorie-free. The United States Food and Drug Administration (FDA)
has approved four non-nutritive sweeteners for use in food: acesulfame K, aspartame,
saccharin, and, sucralose.
Varieties
Acesulfame K
Acesulfame K (Sunette®), or acesulfame potassium, was discovered in 1967 in Germany.
It was approved in 1988 by the FDA as a tabletop sweetener and for use in baked goods, frozen
desserts, beverages, and candies. Consisting of carbon, nitrogen, oxygen, hydrogen, sulfur,
and potassium atoms, acesulfame K is 200 times sweeter than table sugar. Acesulfame K is not
digested, so it contributes no calories to the diet. Some animal studies suggest a possible
cancer-promoting effect.
Aspartame
Aspartame (NutraSweet®) was discovered in 1969, and in 1981 was approved by the FDA
for use in foods. Aspartame is produced from two amino
acids—aspartic acid and
phenylalanine—and is 180 times sweeter than sucrose. Although the FDA points to more
than 100 scientific experiments that purportedly document the safety of aspartame, many
consumers and scientists are not convinced that long-term daily intake of aspartame is
completely safe, and are concerned about the growing number of foods that contain this
ingredient. Aspartame intake is known to be dangerous for persons with phenylketonuria, a metabolic disorder that results in
dangerously high blood levels of phenylalanine. In addition, aspartame is not recommended for
use by pregnant or lactating women.
Saccharin
Saccharin (Sweet’N Low®) was discovered in 1879, and is currently produced from
a purified compound found in coal tar. Saccharin is 300 times sweeter than sugar, but has a
slightly bitter or metallic aftertaste. It is not metabolized in the digestive tract and is
excreted rapidly in the urine. As a result, saccharin does not contribute calories to the
diet. Three scientific experiments in the early 1970s suggested that saccharin might be a
carcinogen (cancer-causing substance) when given to rats in large doses. In response, the FDA
proposed a ban on saccharin for all uses except as an over-the-counter drug. Significant
public opposition to the FDA ban on saccharin ensued, prompting the FDA to pass the Saccharin
Study and Labeling Act in 1977, which placed a two-year moratorium on any ban of the sweetener
until further research was available. The law also required that any foods containing
saccharin must carry a label that reads, “Use of this product may be hazardous to your
health. This product contains saccharin which has been determined to cause cancer in
laboratory animals.” Most long-term animal studies have found no cancer-causing effects
from saccharin consumption. On December 15, 2000, Congress passed legislation to remove the
warning label that had been required on saccharin-sweetened foods and beverages since 1977.
The National Toxicology Program has removed saccharin from its list of cancer-causing
substances.
Sucralose
Sucralose was discovered in 1976, and has been used as a sweetener in foods and beverages
in more than 30 countries, including Canada, Australia, and Mexico. In 1998, the FDA approved
it as a tabletop sweetener and for use in baked goods, beverages, gelatin, and frozen dairy
desserts. In 1999, FDA expanded the approved uses for sucralose, allowing it as a
general-purpose sweetener for all foods. Sucralose is derived from sucrose (table sugar); it
closely resembles table sugar in taste, is highly water-soluble, and is exceptionally stable
at high temperatures. Sucralose is not absorbed from the digestive tract, so it adds no
calories to consumed food. In addition, sucralose does not increase blood sugar levels.
Equal®
Equal is an artificial sweetener containing aspartame, dextrose, and maltodextrin.
Alitame
Like aspartame, Alitame is made from amino acids. Alitame is 2,000 times sweeter than
sugar. Pfizer, a pharmaceutical company and manufacturer of this sweetener, petitioned the FDA
in 1986 for approval. As of 1992, the approval is still pending.
Cyclamate
Cyclamate was synthesized in 1937 at the University of Illinois by a student who
accidentally discovered its sweet taste. The patent for cyclamate was first purchased by
DuPont and then later sold to Abbott Laboratories. In those days, Abbott’s reported
interest was to use the product to mask the bitter taste of an antibiotic and a pentobarbital
elixir. Cyclamate was initially marketed as tablets that were recommended for use as a
tabletop sweetener for people with diabetes and others
who had to restrict their intake of sugar. Although it is approved for use in many countries,
cyclamate is banned in the United States due to concerns over potential carcinogenicity.
Buying and storing tips
Saccharin, aspartame, sucralose, and acesulfame K have very long shelf lives. Store in
original packaging in a dry location at room temperature.
Availability
Saccharin is available worldwide as a tabletop sweetener under the brand name Sweet’N
Low®. It is also found in “diet” soft drinks. Aspartame is available as a
tabletop sweetener under the brand name Equal®. It is also sold as NutraSweet®, an
ingredient found in many “diet” beverages and in many “sugar-free”
foods, including chewing gum, cereals, candies, and desserts. Sucralose is known by its trade
name, Splenda®, and is available as a tabletop sweetener and in many processed foods.
Acesulfame K is sold as a tabletop sweetener under the trade name Sunette®, and appears
in a wide variety of processed foods. Alitame and Cyclamate are not available in the United
States.
Preparation, uses, and tips
Non-nutritive sweeteners can be used in place of table sugar to sweeten hot and cold
beverages. In addition, saccharin, sucralose, and acesulfame K are heat-stable and are
suitable for baking. Keep in mind that non-nutritive sweeteners carry more intense sweetness
than sugar. When substituting these products for sugar, only small amounts are needed to
achieve the same level of sweetness. As a result, quantity modifications of several
ingredients in a recipe may be necessary to accommodate the use of saccharin, sucralose, or
acesulfame K.
Nutritional Highlights
Acesulfame K, 1g
Calories: 0.0
Protein: 0.0g
Carbohydrate: 0.0g
Total Fat: 0.0g
Fiber: 0.0g
Aspartame, 1 packet (1g)
Calories: 0.0
Protein: 0.0g
Carbohydrate: less than 1.0g
Total Fat: 0.0g
Fiber: 0.0g
Sucralose, 1 packet (1g)
Calories: 0.0
Protein: 0.0g
Carbohydrate: 0.0g
Total Fat: 0.0g
Fiber: 0.0g
Health benefits and concerns
Hives
Artificial sweeteners (e.g., aspartame) are among the food additives that have been shown
to trigger hives.
Migraine
Ingestion of the artificial sweetener aspartame has been reported to trigger migraines in a
small proportion of people.
MSG sensitivity
People who are sensitive to MSG may also react to aspartame.
Phenylketonuria
(PKU)
There is debate about whether it is safe for people with PKU to consume aspartame, a
low-calorie sweetener that contains about 50%
phenylalanine. In one study, blood levels of phenylalanine increased only slightly after
people with PKU consumed a 12-oz. soft drink sweetened with aspartame. However, that study did
not address long-term effects of regular aspartame consumption.
Health benefits and
concerns for sweeteners
Many health benefits and concerns associated with this food are applicable to other
sweeteners. Read about health benefits and concerns
for sweeteners for a full description.
Copyright © 2004 Healthnotes, Inc. All rights reserved.
www.healthnotes.com
Learn more about Healthnotes, the company.
Learn more about the authors of
Foodnotes.
The information presented in Foodnotes is for informational
purposes only and was created by a team of U.S. registered dietitians and food experts.
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using
any supplements, making dietary changes, or before making any changes in prescribed
medications. Information expires March 2005.
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